Cystathioninuria can be caused by two different mutations in the enzyme cystathionase. Cystathioninuria caused by mutation 1 can be overcome by providing cells with increasing concentrations of the coenzyme pyridoxal phosphate. Which of the following statements describe the most likely changes in the binding affinities of the two mutant enzymes?
A. Both mutant enzymes have lost the ability to bind the substrates.
B. The enzyme with mutation 1 has lost the ability to bind to the substrates, whereas the enzyme with mutation 2 has lost the ability to bind to pyridoxal phosphate.
C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.
D. Both mutant enzymes have lost the ability to bind pyridoxal phosphate.

Answers

Answer 1

Answer:

C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.

Explanation:

A coenzyme is an organic cofactor that binds with an enzyme in order to initiate or aid the function of the enzyme. A coenzyme binds to the active site of the enzyme (where the reaction occurs), thereby triggering its activation by modifying protein structure during the reaction. Some examples of coenzymes include Coenzyme A and Adenosine triphosphate (ATP). Pyridoxal phosphate is a coenzyme (it is the active form of vitamin B6) that is required for the function of cystathionase. Moreover, cystathionase is an enzyme that enables cells the synthesis of cysteine from methionine (transsulfuration pathway). The binding of pyridoxal phosphate to the enzyme increases the binding affinity of the enzyme for the substrate, thereby influencing its activity. In this case, it is expected that mutation 1 reduces the binding affinity of the enzyme to the cofactor, and thereby the cofactor is required at a higher concentration to restore normal enzyme activity.


Related Questions

Base your answer(s) to the following question on the diagrams below and your knowledge of biology. The diagrams represent two different cells and some of their parts. The diagrams are not drawn to scale. Which statement best describes these cells?

Answers

Answer:

The diagrams represent two different cells and some of their parts. The diagrams are not drawn to scale.

Explanation:

A hole in the skin causes platelets to
rush to the site and release a chemical
that releases more platelets. This is an
example of what type of mechanism?

Answers

Answer:

b number positive feedback

"A hole in the skin causes platelets to rush to the site and release a chemical that releases more platelets" is an example of a positive feedback mechanism. The correct option is B.

What is a positive feedback mechanism?

A positive feedback mechanism is a technique of the body in which the body works or secretes something to the body that is needed more in the body, and it is secreted in the body out of league and number.

Platelets are present in the blood. They are spherical and are colorless and small. They help in blood clotting when there is a cut or bleeding, it prevents loss of blood by clotting the blood.

So, in the hole of the body, there will be blood loss, and releasing more platelets would help in blood clotting.

Thus, the correct option is B. positive feedback mechanism.

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Anything made from crude oil or natrual gas can be made from synthetic oil.
True
Or
False

Answers

Answer: True but not always

Guys how to convince my dad to give me money

Answers

Answer:

hey dad can i have some money

if he says no

then no

Explanation:

Answer:

First ask for a small amount than right after he gives you the small amount ask for a bigger amount

This trick works all the time

Explanation:


Antibodies, lymphocytes, B
cells, and T cells are all a part
of which type of immune
system defense?

Answers

Answer:

A

Explanation:

specific immune defense system

In translation What are are the three letters called in mRNA and what are they connected to ??

Answers

Answer:

During translation, the ribosome reads 3 letters at a time on the mRNA strand called a codon. The anticodons, which are connected to the amino acid, match up with the letters on the mRNA strand  

Explanation:


During photosynthesis,
is used to break water down into oxygen and hydrogen.

Answers

Answer:

yes it is correct answer ........

When might you take a deep breath?

Answers

Answer:

When you're stressed??

Explanation:

i don't really know I never learned this, but I hope this helps

Answer:

In fresh morning......or when ur stressed......or simply when u feel like .......

How do bogs keep themselves cool

Answers

Answer: Like humans, dogs need to keep themselves cool to protect their bodies. They do sweat, but not in the same way. They only have sweat glands only on the paw pads and nose leather. Since they are covered with fur, it is more challenging to keep their bodies cool.

After your dog runs around, you will notice that he begins to pant heavily. Dogs rely on panting to keep their bodies cool. Panting causes the evaporation of water from the nasal cavity, tongue, throat and lungs, which helps lower their body temperature.

They also experience the same dilation in blood vessels as humans, which brings blood to the surface of the skin, allowing the air in the environment to cool them.

Any dog is at risk for heat-related problems, especially in warm, humid weather. Our brachycephalic friends are at a much greater risk than their long-nosed counterparts. Large breeds with thick coats, such as Bernese Mountain dogs or Pyrenees are also more prone. Dogs with pre-existing heart conditions or respiratory issues are also more likely to be overcome by the heat.

When these dogs pant to try and cool themselves, they have to work harder to do so. This only raises their body temperature even higher, making it worse instead of better.

If you gently bend your ear, and then let go, the shape of your ear will return because the cartilage of your ear contains_____.

Answers

Answer:

If you gently bend your ear, and then let go, the shape of your ear will return because the cartilage of your ear contains elastic fibers.

John had unattached earlobes like his father, but his mother has attached earlobes. What is johns genotype with unattached being dominant

Answers

Genotype refers to the complete genetic make-up and can also be referred to as the alleles an organism carries on a particular gene.

John's genotype with unattached being dominant is Aa.

Using A to represent the allelesSince his mother has attached earlobes, her condition can only be inherited in the recessive condition (aa). So for John to have an unattached earlobe, his father has to be either AA or Aa. Therefore John's genotype would be Aa

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Read the following passage and answer the question.

“Never another master kind as he!

I’ll never find one – no matter where I go,

not even if I went back to mother and father,

the house where I was born and my parents reared me once.

Ah, but much as I grieve for them, much as I long

to lay my eyes on them. Set food on the old soil,

it’s longing for him, him that wrings my heart –

Odysseus, lost and gone!

That man, old friend, far away as he is…

I can scarcely bear to say his name aloud,

so deeply he loved me, cared for me, so deeply.

Worlds away as he is, I call him my Master, Brother!”

Which theme is being expressed in this passage?

hospitality
temptation
pride
loyalty

Answers

Answer:

it's like two theme there

Explanation:

hospitality or loyalty

A. Form a new question that relates to the interaction of organisms in the ecosystem.

Answers

Answer:Predation, parasitism and herbivory are the three interactions which are found in different organisms of an ecosystem.

Lion is a predator which feed on flesh of other animals such as herbivores.

Explanation:

A mother has blood type A and her son has blood type O. Which blood types are possible for the father?

Answers

Answer: The child fathers blood type is O.

Use the story below to fill in the questions.



A) Origin and development









B) Earth











C) Life











D) Early technologies

Answers

Answer:

letter A

Explanation:

because the story about the creation of the Maya Narration is discuss about the past world earth who there was no light,no electricity,no cellphone,no have technologies and it's silence after so many people have come and birth in the world,so many changes have done,we have now connection in our society in social and in reality,that ultimately is producing true,and enduring.

what is Nuclear Fusion. ​

Answers

Answer: Nuclear Fusion occurs when the nuclear components of an atom combine.

Select all that apply. Hair infections are generally
caused by
bacteria.
fungi.
viruses.
ODO
cancer.
lice.
DONE

Answers

Answer: A. Bacteria, B. Fungi, E. Lice.

Explanation:

PLEASE HELP!! 70 POINTS!!!
Explain how DNA is involved in creating genetic variation within a species. Is this considered a mutation, if so why?

Answers

Answer:

different strands creates different human characteristic

Could there be winds without differential heating? Using evidence from Unit 5 explain what differential heating is and whether this effects the earth’s global wind patterns.
HELPPP PLEASE SITE EVIDENCE (WILL MARK BRAINLIEST)!!!!!!!!

Answers

Differential heating is responsible for the wind patterns across the globe.

Differential heating is defined as the difference in heating of air on the land versus water. Sea breezes occur when land heats up faster than water which rises and creates a low pressure system. The high pressure air from the sea influxes is responsible for the creation of a sea breeze.

Unequal heating of the Earth's surface is responsible for the formation of large global wind patterns. Warm air rises at the equator and moves toward the poles while on the other hand, the cooler air rises at the poles and moves back toward the equator so in this way the earth’s global wind patterns occurs so we can say that differential heating is responsible for the wind patterns across the globe.

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b) What is the name of the tube that connects the liver to the alimentary canal?

Answers

Answer:

Tube is a connected liver alimentary canal

Explanation:

Tube id miob

g persons with the inherited disease familial hypercholesterolemia have very high levels of cholestoral because of

Answers

Answer:

a genetic mutation passed on by one or two of their parents.

Explanation:

What would happen if any of the biogeochemical cycles would break

Answers

Answer:

Excess phosphorus is polluting our environment while, ironically, mineable resources of this essential nutrient are limited. Globally, oxygen-depleted marine coastal 'dead zones' caused by nutrient-stimulated algal blooms continue to expand

Explanation:

- Psychology PLS HELP-

Tom's directive and confrontive therapist challenges Tom's belief that he is worthless because he is not the
world's greatest Superhero. Tom's therapist is most likely:

A. an eclectic therapist

B. a psychoanalyst like Sigmund Freud

C. a cognitive therapist like Aaron Beck

D. a humanistic therapist like Carl Rogers

E. a humanistic, client-centered therapist

Answers

Tom's therapist is most likely an eclectic therapist.

What is eclectic therapy?

Eclectic therapy is a method that draws on orientation and many theoretical approaches. It is a flexible and multi-faceted treatment that allows the therapist to use the most effective methods available to address the needs of each client.

What is an example of eclectic therapy?

An example of an eclectic program is where children spend part of each day experiencing a variety of treatments, such as formal teaching using behavioral analytical techniques (ABA), sensory stimulation (brushing and flipping), down-to-earth routines, and music sessions, and free play with regular peers.

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diegetic sound in the film monkeys paw 2011

Answers

That your digestive monkeys are from the ancient sanctuaries of the ancient Egyptian Mona Lisa in 2011 Mona Lisa is took a mayonnaise piece of bread and smooshed it onto the ancient Egyptian men for disrespecting her culture because the ancient Egyptian men wanted to dress like blatant don’t know what I’m saying just kidding hi

when did large mouth bass arrive in nebraska

Answers

Explanation:

around 1880 and 1883

i think

1885 is the correct answer

please help :(
Which of the following defines a cash crop?


any crop grown to be sold for direct sale

any crop grown to be sold to other growers

any crop grown to be sold as a raw material

any crop grown to be sold on the commodities market

Answers

Answer:

Any crop grown to be sold for Direct sale

A cash crop or profit crop is an agricultural crop which is grown to sell for profit. ... The term is used to differentiate marketed crops from subsistence crops, which are those fed to the producer's own livestock or grown as food for the producer's family.

Hope this helps you!!

Solar radiation can cause skin cancer in an individual. If a man with skin cancer caused by solar radiation has offspring, which of the following statements would be true? A. only the man getting skin cancer would be affected B. only the man and his male offspring would be affected C. only the man and his female offspring would be affected D. the man and all of his offspring would be affected

Answers

A. Only the man as it cannot be inherently passed on to offsprings

Can Glucose turn into fat

Answers

Answer:

yea

Explanation:

If u consume to much or have diabetes its cant run it so it turns into fat

this is my question ​

Answers

Answer: B

Explanation: im sorry if this is wrong

Have a great day.

it’s the first answer A

which is true about a hypotonic solution? a. it has a higher concentration of wtwr and a lower concentration of solutes than another solution
b. ut has a higher concentration of solutes and a lower concentration of water than other solution
c. it has an equal concentration of water and solutes as another solution
d. it has more solutes than solvent than another solution

Answers

Answer:

A

Explanation:

A hypotonic solution has a lower concentration of solutes than another solution, but has more water.

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